Design and synthesis of sugar-triazole based uracil appended sugar-imine derivatives – an application in DNA binding studies

Hemamalini, Arasappan ; Azhagiya Singam, Ettayapuram Ramaprasad ; Mudedla, Sathish Kumar ; Subramanian, Venkatesan ; Mohan Das, Thangamuthu (2015) Design and synthesis of sugar-triazole based uracil appended sugar-imine derivatives – an application in DNA binding studies New Journal of Chemistry, 39 (6). pp. 4575-4582. ISSN 1144-0546

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Official URL: http://pubs.rsc.org/en/content/articlelanding/2015...

Related URL: http://dx.doi.org/10.1039/C4NJ02221A

Abstract

Several sugar-triazole derivatives were synthesized and characterized by spectroscopic techniques. The interaction of the sugar-triazoles with CT-DNA was explored, which revealed that all the compounds could interact with CT-DNA through groove binding, which was further supported by a docking analysis.

Item Type:Article
Source:Copyright of this article belongs to Royal Society of Chemistry.
ID Code:107156
Deposited On:01 Dec 2017 12:36
Last Modified:01 Dec 2017 12:36

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