Tandon, N. ; Mehra, N. K. ; Taneja, V. ; Vaidya, M. C. ; Kochupillai, N. (1990) HLA antigens in Asian Indian patients with Graves' disease Clinical Endocrinology, 33 (1). pp. 21-26. ISSN 0300-0664
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Official URL: http://onlinelibrary.wiley.com/doi/10.1111/j.1365-...
Related URL: http://dx.doi.org/10.1111/j.1365-2265.1990.tb00461.x
Abstract
A study of 57 Asian Indian patients with Graves'disease revealed a significant increase in the frequency of HLA-DQW2 (61.4%) as compared to the control population (22.6%) giving a relative risk of 5.4. Less prominent but statistically significant increase in the frequency of HLA-A10 (29.8% patients as opposed to 10.5% controls) and HLA-B8 (28.1% patients as opposed to 8.7% controls) was also observed. Further, patients carrying the phenotypes HLA-A10 and HLA-B8 were more prone to develop the disease at a younger age. Two HLA haplotypes, namely A10-B8 and B8-DR3, were found in significant linkage disequilibrium in our patients with Graves'disease. Patients carrying these haplotypes also had a tendency to develop the disease at an earlier age.
Item Type: | Article |
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Source: | Copyright of this article belongs to John Wiley and Sons Inc. |
ID Code: | 107108 |
Deposited On: | 22 Jun 2017 11:58 |
Last Modified: | 22 Jun 2017 11:58 |
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