Mehra, N. K. ; Kaur, Gurvinder ; Kanga, Uma ; Tandon, Nikhil (2006) Immunogenetics of autoimmune diseases in Asian Indians Annals of the New York Academy of Sciences, 958 (1). pp. 333-336. ISSN 0077-8923
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Official URL: http://onlinelibrary.wiley.com/doi/10.1111/j.1749-...
Related URL: http://dx.doi.org/10.1111/j.1749-6632.2002.tb02999.x
Abstract
The HLA class II molecules play a critical role in the processing and presentation of specific peptides derived from autoantigens of pancreatic beta cells or gluten for T cell scrutiny in IDDM and CD. In the present study, extended DR3-positive haplotypes associated with autoimmunity in northern Indian patients have been reported. The haplotype A26-B8-DR3 was the most common autoimmunity-favoring haplotype encountered among these patients. This association is, indeed, unique to Indian autoimmune patients, as it replaces the otherwise most commonly associated Caucasian haplotype A1-B8-DR3 (AH8.1) in this population. Further, CD patients revealed 100% association with DQB1*0201 along with DQA*0501 (97%) either in cis or trans configuration.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to John Wiley and Sons Inc. |
| ID Code: | 107082 |
| Deposited On: | 23 Jun 2017 07:11 |
| Last Modified: | 23 Jun 2017 07:11 |
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