Common variants of homocysteine metabolism pathway genes and risk of type 2 diabetes and related traits in Indians

Chauhan, Ganesh ; Kaur, Ismeet ; Tabassum, Rubina ; Dwivedi, Om Prakash ; Ghosh, Saurabh ; Tandon, Nikhil ; Bharadwaj, Dwaipayan (2012) Common variants of homocysteine metabolism pathway genes and risk of type 2 diabetes and related traits in Indians Experimental Diabetes Research, 2012 . Article ID 960318, 7 pages. ISSN 1687-5214

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Official URL: https://www.hindawi.com/journals/jdr/2012/960318/

Related URL: http://dx.doi.org/10.1155/2012/960318

Abstract

Hyperhomocysteinemia, a risk factor for cardiovascular disorder, obesity and type 2 diabetes, is prevalent among Indians who are at high risk of these metabolic disorders. We evaluated association of common variants of genes involved in homocysteine metabolism or its levels with type 2 diabetes, obesity, and related traits in North Indians. We genotyped 90 variants in initial phase (2.115 subjects) and replicated top signals in an independent sample set (2.085 subjects). The variant MTHFR-rs1801133 was the top signal for association with type 2 diabetes (OR = 0.78 (95% CI = 0.67–0.92), P = 0.003) and was also associated with 2 h postload plasma glucose (P = 0.04), high-density lipoprotein cholesterol (P = 0.004) and total cholesterol (P = 0.01) in control subjects. These associations were neither replicated nor significant after meta-analysis. Studies involving a larger study population and different ethnic groups are required before ruling out the role of these important candidate genes in type 2 diabetes, obesity and related traits.

Item Type:Article
Source:Copyright of this article belongs to Hindawi Publishing Corporation
ID Code:107012
Deposited On:25 Jun 2017 08:18
Last Modified:25 Jun 2017 08:21

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