Copper(II)-catalyzed oxidative cross-coupling of anilines, primary alkyl amines, and sodium azide using TBHP: a route to 2-substituted benzimidazoles

Mahesh, Devulapally ; Sadhu, Pradeep ; Punniyamurthy, Tharmalingam (2016) Copper(II)-catalyzed oxidative cross-coupling of anilines, primary alkyl amines, and sodium azide using TBHP: a route to 2-substituted benzimidazoles The Journal of Organic Chemistry, 81 (8). pp. 3227-3234. ISSN 0022-3263

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Official URL: http://pubs.acs.org/doi/abs/10.1021/acs.joc.6b0018...

Related URL: http://dx.doi.org/10.1021/acs.joc.6b00186

Abstract

Copper(II)-catalyzed oxidative cross-coupling of anilines, primary alkyl amines, and sodium azide is described in the presence of TBHP at moderate temperature. This one-pot multicomponent protocol involves a domino C–H functionalization, transimination, ortho-selective amination, and a cyclization sequence. The broad substrate scope and functional group compatibility are the significant practical features. The protocol can be extended to the coupling of benzyl alcohols with moderate yields.

Item Type:Article
Source:Copyright of this article belongs to American Chemical Society.
ID Code:106954
Deposited On:22 Jun 2017 10:00
Last Modified:22 Jun 2017 10:00

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