Lipid flip-flop driven mechanical and morphological changes in model membranes

Ramachandran, Sanoop ; Sunil Kumar, P. B. ; Laradji, Mohamed (2008) Lipid flip-flop driven mechanical and morphological changes in model membranes Journal of Chemical Physics, 129 (12). Article ID 125104. ISSN 0021-9606

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Official URL: http://aip.scitation.org/doi/10.1063/1.2981564

Related URL: http://dx.doi.org/10.1063/1.2981564

Abstract

We study, using dissipative particle dynamics simulations, the effect of active lipid flip-flop on model fluid bilayer membranes. We consider both cases of symmetric as well as asymmetric flip-flops. Symmetric flip-flop leads to a steady state of the membrane with an effective temperature higher than that of the equilibrium membrane and an effective surface tension lower than that of the equilibrium membrane. Asymmetric flip-flop leads to transient conformational changes in the membrane in the form of bud or blister formation, depending on the flip rate.

Item Type:Article
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ID Code:106773
Deposited On:01 Feb 2018 11:57
Last Modified:01 Feb 2018 11:57

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