Punniyamurthy, Tharmalingam ; Paul, Rajesh ; Ali, Md (2010) Copper-catalyzed hydroxylation of aryl halides with tetrabutylammonium hydroxide: synthesis of substituted phenols and alkyl aryl ethers Synthesis, 2010 (24). pp. 4268-4272. ISSN 0039-7881
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Official URL: https://www.thieme-connect.com/products/ejournals/...
Related URL: http://dx.doi.org/10.1055/s-0030-1258965
Abstract
The selective hydroxylation of aryl iodides and aryl bromides with tetrabutylammonium hydroxide pentahydrate is described. For this, the combination of copper(I) iodide and 8-hydroxyquinaldine at 70-130 ˚C in a mixture of dimethyl sulfoxide and water (2:3) is used. The resultant phenols can be readily reacted with alkyl and allyl halides in situ to provide the corresponding alkyl or allyl aryl ethers in high yields. The reactions are simple, general, and efficient, affording substituted phenols and alkyl aryl ethers under aerobic conditions.
Item Type: | Article |
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Source: | Copyright of this article belongs to Thieme Medical Publishers Inc. |
Keywords: | Phenols; Copper Iodide; Tetrabutylammonium Hydroxide Pentahydrate; Aryl Halides; Hydroxylation |
ID Code: | 106440 |
Deposited On: | 22 Jun 2017 10:22 |
Last Modified: | 22 Jun 2017 10:22 |
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