2-Aroylindoles from o-bromochalcones via Cu(i)-catalyzed SNAr with an azide and intramolecular nitrene C–H insertion

Goriya, Yogesh ; Ramana, Chepuri V. (2014) 2-Aroylindoles from o-bromochalcones via Cu(i)-catalyzed SNAr with an azide and intramolecular nitrene C–H insertion Chemical Communications, 50 (58). pp. 7790-7792. ISSN 1359-7345

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Official URL: http://pubs.rsc.org/en/Content/ArticleLanding/2014...

Related URL: http://dx.doi.org/10.1039/C4CC02501F

Abstract

A simple procedure for the synthesis of 2-aroylindole derivatives comprising a one-pot CuI-catalyzed SNAr reaction of o-bromochalcones with sodium azide and subsequent intramolecular cyclization through nitrene C–H insertion has been developed. This protocol is also applicable with the 2′-bromocinnamates giving the indole-2-carboxylates.

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