Ramana, Chepuri V. ; Swami, Anuradha (2015) Target cum flexibility: Synthesis of indolo[1,2-b]isoquinoline derivatives via cobalt-catalyzed [2+2+2] cyclotrimerization Synlett, 26 (05). pp. 604-608. ISSN 0936-5214
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Official URL: https://www.thieme-connect.com/products/ejournals/...
Related URL: http://dx.doi.org/10.1055/s-0034-1379950
Abstract
A modular approach for the synthesis of small molecules having the unnatural 6,11-dihydroindolo[1,2-b]isoquinoline tetracyclic core has been documented. An acid-catalyzed Friedel–Crafts-type C2-alkylation of N-propargyl indole with a suitably activated alkynol has been used to prepare the key indole-derived diynes. The cobalt-catalyzed [2+2+2] cyclotrimerization of these diynes has been studied with various internal/terminal alkynes and with nitriles.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Thieme Publishing. |
| Keywords: | [2+2+2] Cyclotrimerization; Cobalt; Indole; Indolo[1,2-b]; Isoquinoline; Pyridine |
| ID Code: | 105925 |
| Deposited On: | 01 Feb 2018 16:50 |
| Last Modified: | 01 Feb 2018 16:50 |
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