Target cum flexibility: Synthesis of indolo[1,2-b]isoquinoline derivatives via cobalt-catalyzed [2+2+2] cyclotrimerization

Ramana, Chepuri V. ; Swami, Anuradha (2015) Target cum flexibility: Synthesis of indolo[1,2-b]isoquinoline derivatives via cobalt-catalyzed [2+2+2] cyclotrimerization Synlett, 26 (05). pp. 604-608. ISSN 0936-5214

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Related URL: http://dx.doi.org/10.1055/s-0034-1379950

Abstract

A modular approach for the synthesis of small molecules having the unnatural 6,11-dihydroindolo[1,2-b]isoquinoline tetracyclic core has been documented. An acid-catalyzed Friedel–Crafts-type C2-alkylation of N-propargyl indole with a suitably activated alkynol has been used to prepare the key indole-derived diynes. The cobalt-catalyzed [2+2+2] cyclotrimerization of these diynes has been studied with various internal/terminal alkynes and with nitriles.

Item Type:Article
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Keywords:[2+2+2] Cyclotrimerization; Cobalt; Indole; Indolo[1,2-b]; Isoquinoline; Pyridine
ID Code:105925
Deposited On:01 Feb 2018 16:50
Last Modified:01 Feb 2018 16:50

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