Enantiospecific synthesis of (−)-muricatacin from L-(+)-tartaric acid

Prasad, Kavirayani R. ; Anbarasan, Pazhamalai (2006) Enantiospecific synthesis of (−)-muricatacin from L-(+)-tartaric acid Tetrahedron: Asymmetry, 17 (17). pp. 2465-2467. ISSN 0957-4166

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Official URL: http://www.sciencedirect.com/science/article/pii/S...

Related URL: http://dx.doi.org/10.1016/j.tetasy.2006.09.017

Abstract

Enantiospecific synthesis of (−)-muricatacin, a bio-active lactone comprising of a 5-hydroxyalkylbutan-4-olide structural component has been achieved from L-(+)-tartaric acid. The key step involves a disteroselective reduction of a C2-symmetric 1,4-diketone derived from tartaric acid followed by a selective Grignard reagent addition.

Item Type:Article
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ID Code:105838
Deposited On:21 Dec 2017 12:04
Last Modified:21 Dec 2017 12:04

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