Enantioselective total synthesis of iso-cladospolide B, cladospolide C and cladospolide B from tartaric acid

Prasad, Kavirayani R. ; Gandi, Vasudeva Rao (2011) Enantioselective total synthesis of iso-cladospolide B, cladospolide C and cladospolide B from tartaric acid Tetrahedron: Asymmetry, 22 (5). pp. 499-505. ISSN 0957-4166

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Official URL: http://www.sciencedirect.com/science/article/pii/S...

Related URL: http://dx.doi.org/10.1016/j.tetasy.2011.02.018

Abstract

The enantioselective synthesis of the natural products cladospolide B, cladospolide C, and iso-cladospolide B has been accomplished from tartaric acid. Key reactions in the synthetic sequence include the elaboration of a γ-hydroxy amide derived from tartaric acid via alkene cross metathesis, Yamaguchi lactonization, and ring closing metathesis.

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