Kar, Mrityunjoy ; Vijayakumar, P. S. ; Prasad, B. L. V. ; Gupta, Sayam Sen (2010) Synthesis and characterization of poly-L-lysine-grafted silica nanoparticles synthesized via NCA polymerization and click chemistry Langmuir, 26 (8). pp. 5772-5781. ISSN 0743-7463
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Official URL: http://pubs.acs.org/doi/abs/10.1021/la903595x
Related URL: http://dx.doi.org/10.1021/la903595x
Abstract
Polypeptide polymer-grafted silica nanoparticles are of considerable interest because the ordered secondary structure of the polypeptide grafts imparts novel functional properties onto the nanoparticle composite. The synthesis of poly-L-lysine-grafted silica nanoparticles would be of particular interest because the high density of cationic charges on the surface could lead to many applications such as gene delivery and antimicrobial agents. In this work, we have developed a “grafting-to” approach using a combination of NCA polymerization and “click chemistry” to synthesize poly-L-lysine-grafted silica nanoparticles with a high graft density of 1 chain/nm2. The covalent attachment of poly-L-lysine to silica nanoparticles (PLL−silica) was confirmed using a variety of techniques such as 13C CP MAS NMR, TGA and IR. This methodology was then extended to graft poly-L-lysine-b-poly-L-leucine copolymer (PLL-b-PLLeu−silica) and poly-L-benzylglutamate (PLBG−silica) onto silica nanoparticles. All of these polypeptide-grafted nanoparticles show interesting aggregation properties in solution. The efficacy of PLL−silica and PLL-b-PLLeu−silica as antimicrobial agents was tested on both gram-negative E. coli and gram-positive Bacillus subtilis.
Item Type: | Article |
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Source: | Copyright of this article belongs to American Chemical Society. |
ID Code: | 105409 |
Deposited On: | 01 Feb 2018 17:13 |
Last Modified: | 01 Feb 2018 17:13 |
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