Synthesis of Ag-glyconanoparticles using C-glycosides, their lectin binding studies and antibacterial activity

Abstract

Two 12-C-glycosyl dodecanoic acids, namely, 1-(α-D-mannopyranosyl)-12-dodecanoic acid and 1-(α-D-glucopyranosyl)-12-dodecanoic acid were synthesized. Their ability to act as reducing and capping agents for the synthesis of water re-dispersible silver nanoparticles is displayed. These Ag C-glycosyl nanoparticles were later utilized to investigate the carbohydrate–lectin interactions. Furthermore, the specificity of mannoside binding to the surface of the Gram negative bacterium Escherichia coli has been utilized to demonstrate the enhanced antibacterial activity of Ag-C-mannosyl nanoparticles towards this bacterium as compared to Ag-C-glycosyl nanoparticles.