Faruqi, Ahmed F. ; Roychoudhury, Susanta ; Greenberg, Richard ; Israel, Jonathan ; Shih, Chiaho (1991) Replication-defective missense mutations within the terminal protein and spacer/intron regions of the polymerase gene of human hepatitis B virus Virology, 183 (2). pp. 764-768. ISSN 0042-6822
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Official URL: http://www.sciencedirect.com/science/article/pii/0...
Related URL: http://dx.doi.org/10.1016/0042-6822(91)91007-4
Abstract
We have analyzed 11 independent mutations located at various domains of the polymerase gene (pol) of human hepatitis B virus. Surprisingly, one of the two missense mutants within the spacer/intron region appears to be lethal. This result further defines the N-terminal limit of the reverse transcriptase domain. Alternatively, it suggests the potential existence of a novel domain with an unknown function. Two missense mutations within the terminal protein (TP) domain appear to be replication-defective as well, suggesting a functionally essential role of the TP domain in DNA replication.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| ID Code: | 105310 |
| Deposited On: | 21 Dec 2017 11:34 |
| Last Modified: | 21 Dec 2017 11:34 |
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