Gowrisankar, Parthasarathy ; Pujari, Sandip A. ; Kaliappan, Krishna P. (2010) A formal total synthesis of palmerolide A Chemistry - A European Journal, 16 (20). pp. 5858-5862. ISSN 0947-6539
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Official URL: http://onlinelibrary.wiley.com/doi/10.1002/chem.20...
Related URL: http://dx.doi.org/10.1002/chem.201000428
Abstract
An efficient formal total synthesis of the marine natural product palmerolide A is reported herein, involving 24 longest linear steps. The key features of our synthesis involve a combination of Sharpless epoxidation and Shimizu reaction to construct the syn aldol moiety, a Julia–Kocienski reaction to construct the diene, and ring-closing metathesis to form the macrocycle.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to John Wiley and Sons, Inc. |
| Keywords: | Antitumor Agents; Julia–Kocienski Reaction; Metathesis; Natural Products; Structure Elucidation |
| ID Code: | 104978 |
| Deposited On: | 19 May 2017 09:43 |
| Last Modified: | 19 May 2017 09:43 |
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