Rao, Jagadeeshwar R. ; Jha, Ashok K. ; Rawal, Ravindra K. ; Sharon, Ashoke ; Day, Craig W. ; Barnard, Dale L. ; Smee, Donald F. ; Chu, Chung K. (2010) (−)-Carbodine: enantiomeric synthesis and in vitro antiviral activity against various strains of influenza virus including H5N1 (avian influenza) and novel 2009 H1N1 (swine flu) Bioorganic & Medicinal Chemistry Letters, 20 (8). pp. 2601-2604. ISSN 0960-894X
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Official URL: http://www.sciencedirect.com/science/article/pii/S...
Related URL: http://dx.doi.org/10.1016/j.bmcl.2010.02.074
Abstract
Enantiomerically pure cyclopentyl cytosine [(−)-carbodine 1] was synthesized from d-ribose and evaluated for its anti-influenza activity in vitro in comparison to the (+)-carbodine, (±)-carbodine and ribavirin. (−)-Carbodine 1 exhibited potent antiviral activity against various strains of influenza A and B viruses.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Carbodine; Carbocyclic Nucleosides; Anti-influenza Activity |
| ID Code: | 104410 |
| Deposited On: | 16 Jun 2017 11:12 |
| Last Modified: | 16 Jun 2017 11:13 |
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