Preparation and properties of chloro-N, N-dialkylamino-2,2,2-trichloroethoxy- and chloro-N, N-dialkylamino-2,2,2-trichloro-1,1-dimethylethoxyphosphines and their deoxynucleoside phosphiteamidates

Hering, G. ; Stöcklein-schneiderwind, R. ; Ugi, I. ; Pathak, T. ; Balgobin, N. ; Chattopadhyaya, J. (1985) Preparation and properties of chloro-N, N-dialkylamino-2,2,2-trichloroethoxy- and chloro-N, N-dialkylamino-2,2,2-trichloro-1,1-dimethylethoxyphosphines and their deoxynucleoside phosphiteamidates Nucleosides and Nucleotides, 4 (1-2). pp. 169-171. ISSN 0732-8311

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Official URL: http://www.tandfonline.com/doi/abs/10.1080/0732831...

Related URL: http://dx.doi.org/10.1080/07328318508077846

Abstract

Trichloroethyl- and trichloro-t-butyl phosphiteamidates building blocks, (2), to (11), have been prepared for DNA synthesis and their relative rates of activation with several acids have been estimated along with two model oligothymidylic acid syntheses on a solid support.

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