Teimoori, Simin ; Panjamurthy, Kuppusamy ; Vinaya, Kambappa ; Prasanna, Doddakunche S. ; Raghavan, Sathees C. ; Rangappa, Kanchugarakoppal S. (2011) Synthesis and biological evaluation of novel homopiperazine derivatives as anticancer agents Journal of Cancer Therapy, 2 (4). pp. 507-514. ISSN 2151-1934
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Official URL: https://www.scirp.org/journal/PaperInformation.asp...
Related URL: http://dx.doi.org/10.4236/jct.2011.24069
Abstract
In search of new anticancer agents, a series of novel 1-benzhydryl-4-(substituted phenylcarboxamide/carbothioamide)-1,4-diazepane derivatives were designed, synthesized and characterized using 1H NMR, LCMS and elemental analysis. These molecules were evaluated for their anti-cancer activity by trypan blue exclusion and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay on B-cell leukemic cell line, Reh. Carboxamide moiety containing derivatives showed good activity compared to the corresponding carbothioamide derivatives. In particular, 4-benzhydryl-N-(3-chlorophenyl)-1,4-diazepane-1-carboxamide showed good activity with IC50 value of 18 μM.
Item Type: | Article |
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Source: | Copyright of this article belongs to Scientific Research Publishing. |
Keywords: | Cancer Therapy; Cytotoxicity; 1,4-Diazepane; Isocyanates; Isothiocyanates |
ID Code: | 104214 |
Deposited On: | 11 Apr 2017 16:24 |
Last Modified: | 01 Feb 2018 10:11 |
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