Bera, Sanjib ; Pathak, Tanmaya (2004) Synthesis and reactions of allenic sulfone-modified thymidine: the first allenic sulfone to alkylate deoxyadenosine Synlett (12). pp. 2147-2150. ISSN 0936-5214
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Official URL: https://www.thieme-connect.com/products/ejournals/...
Related URL: http://dx.doi.org/10.1055/s-2004-832807
Abstract
3'-(S)-(allenic sulfonyl)-5'-benzoyl-3'-deoxythymidine has been synthesized from 1-(5-O-trityl-3-O-mesyl-2-deoxy-β-D-threopentofuranosyl) thymine via 3'-(S)-(propargylthio)-5'-trityl-3'-deoxythymidine in six steps. 3'-(S)-(allenic sulfonyl)-3'-deoxythymidine reacts very efficiently with a wide array of nucleophiles. This is also the first report on the alkylation of adenine moiety by some allenic sulfone modified compounds.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Thieme Medical Publishers Inc. |
| Keywords: | Reactive Nucleosides; Allenic Sulfone; Alkylating Nucleoside |
| ID Code: | 104197 |
| Deposited On: | 17 Mar 2017 09:21 |
| Last Modified: | 17 Mar 2017 09:21 |
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