Katiyar, Arpit ; Hegde, Mahesh ; Kumar, Sujeet ; Gopalakrishnan, Vidya ; Bhatelia, Khyati D. ; Ananthaswamy, Kavya ; Ramareddy, Sureshbabu A. ; De Clercq, Erik ; Choudhary, Bibha ; Schols, Dominique ; Raghavan, Sathees C. ; Karki, Subhas S. (2015) Synthesis and evaluation of the biological activity of N′-[2-oxo-1, 2 dihydro-3 H-indol-3-ylidene] benzohydrazides as potential anticancer agents RSC Advances, 5 (56). pp. 45492-45501. ISSN 2046-2069
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Official URL: http://pubs.rsc.org/en/content/articlelanding/2015...
Related URL: http://dx.doi.org/10.1039/C5RA01528F
Abstract
New N′-[2-oxo-1,2-dihydro-3H-indol-3-ylidene]benzohydrazide derivatives were synthesized and evaluated for their cytotoxic properties against murine leukemia, L1210, human leukemia, REH and K562, human T-cell leukemia, CEM and human cervix carcinoma, HeLa cells. Among the tested compounds, the 3,4,5-trimethoxy-N′-[5-methyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene]benzohydrazide derivative (5t) emerged as the most potent inhibitor against all the tumor cell lines evaluated. To investigate the mechanism of action, 5t was further studied by cell cycle analysis, mitochondrial membrane potential analysis, DNA fragmentation and Annexin V-FITC flow cytometric analysis, which suggested that 5t was able to induce apoptosis at submicromolar range.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Royal Society of Chemistry. |
| ID Code: | 104145 |
| Deposited On: | 07 Apr 2017 06:46 |
| Last Modified: | 07 Apr 2017 06:46 |
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