Pal, Tarun Kumar ; Dey, Tuli ; Chakrabarty, Arindam ; Dey, Debanjana ; Ghosh, Sudip K. ; Pathak, Tanmaya (2010) First synthesis and antiprotozoal activities of divinyl sulfone-modified carbohydrates Bioorganic & Medicinal Chemistry Letters, 20 (12). pp. 3777-3780. ISSN 0960-894X
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Official URL: http://www.sciencedirect.com/science/article/pii/S...
Related URL: http://dx.doi.org/10.1016/j.bmcl.2010.04.056
Abstract
Divinyl sulfone-modified carbohydrates have been synthesized for the first time by reacting easily available carbohydrate epoxides with thioethanol in a regiospecific fashion. One of the modified divinyl sulfones initiated significant cell death in Entamoeba species and the influence of the anomeric configurations on the biological activities of these sugar-derived divinyl sulfones has been highlighted. The most active compound in this series was found to be devoid of any toxicity.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Divinyl Sulfone; Carbohydrates; Antiprotozoal; Entamoeba histolytica; Entamoeba invadens |
| ID Code: | 104011 |
| Deposited On: | 17 Mar 2017 10:49 |
| Last Modified: | 17 Mar 2017 10:49 |
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