Sharath Kumar, Kothanahally S. ; Hanumappa, Ananda ; Hegde, Mahesh ; Narasimhamurthy, Kereyagalahally H. ; Raghavan, Sathees C. ; Rangappaa, Kanchugarakoppal S. (2014) Synthesis and antiproliferative effect of novel 4-thiazolidinone-, pyridine-and piperazine-based conjugates on human leukemic cells European Journal of Medicinal Chemistry, 81 . pp. 341-349. ISSN 0223-5234
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Official URL: http://www.sciencedirect.com/science/article/pii/S...
Related URL: http://dx.doi.org/10.1016/j.ejmech.2014.05.009
Abstract
The present work reveals the synthesis and antiproliferative effect of a series of 2, 3 disubstituted 4-thiazolidinone analogues on human leukemic cells. The chemical structures of newly synthesized compounds were confirmed by IR, 1H NMR, 13C NMR and mass spectral analysis. Compound methyl 3-methoxy-4-(4-oxo-3-(5-(piperazin-1-yl)pyridin-2-yl)thiazolidin-2-yl)benzoate (5) displayed potent activity (IC50509.71, 15.24 and 19.29 μM) against Nalm6, K562, Jurkat cells. Cell cycle analysis and mitochondrial membrane potential further confirmed that compound 5 is cytotoxic and able to induce cell death.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Thiazolidinones; Propylphosphonic Anhydride (T3P®); Leukemia; Cytotoxicity; Chemotherapeutics; Apoptosis |
| ID Code: | 103974 |
| Deposited On: | 11 Apr 2017 16:12 |
| Last Modified: | 11 Apr 2017 16:13 |
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