Chiruvella, Kishore K. ; Kari, Vijayalakshmi ; Choudhary, Bibha ; Nambiar, Mridula ; Ghanta, Rama Gopal ; Raghavan, Sathees C. (2008) Methyl angolensate, a natural tetranortriterpenoid induces intrinsic apoptotic pathway in leukemic cells FEBS Letters, 582 (29). pp. 4066-4076. ISSN 0014-5793
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Official URL: http://www.sciencedirect.com/science/article/pii/S...
Related URL: http://dx.doi.org/10.1016/j.febslet.2008.11.001
Abstract
Methyl Angolensate (MA), a natural tetranortriterpenoid, purified from Soymida febrifuga is examined for the first time for its anticancer properties. We find that MA inhibits growth of T-cell leukemia and chronic myelogenous leukemia cells in a time- and dose-dependent manner. Accumulation of cells in the subG1 peak, annexin V binding and DNA fragmentation suggested induction of apoptosis. Besides, upregulation of BAD (proapoptotic) and downregulation of BCL2 (antiapoptotic) gene products further supported induction of apoptosis. Loss of mitochondrial membrane potential, activation of caspase 9, caspase 3, cleavage of PARP, downregulation of Ku70/80 and phosphorylation of MAP kinases suggested that MA could induce intrinsic pathway of apoptosis in leukemic cells.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to John Wiley and Sons Inc. |
| Keywords: | Cytotoxicity; Double-strand Break; Cancer Therapeutics; Chemotherapy; Callus; DNA Damage |
| ID Code: | 103909 |
| Deposited On: | 13 Apr 2017 12:07 |
| Last Modified: | 13 Apr 2017 12:07 |
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