Manna, Chinmoy ; Samanta, Sintu Kumar ; Ghosh, Sudip Kumar ; Pathak, Tanmaya (2013) Synthesis of 1,8-dioxooctahydroxanthene C-nucleosides Tetrahedron Letters, 54 (30). pp. 3971-3973. ISSN 0040-4039
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Official URL: http://www.sciencedirect.com/science/article/pii/S...
Related URL: http://dx.doi.org/10.1016/j.tetlet.2013.05.067
Abstract
Since reactions between carbohydrates and cyclic 1,3-dicarbonyl compounds do not produce 1,8-dioxooctahydroxanthenes in general, reaction strategies have been devised to generate new 1,8-dioxooctahydroxanthene C-nucleosides by reacting sugars masked with acid-labile protecting groups and with free hydroxyl groups with 1,3-cyclohexanedione or dimedone. Some of these compounds are more cytotoxic to the cancer cells than against normal fibroblasts.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | 1,8-Dioxooctahydroxanthene C-nucleosides; Cyclic Sugar Aldehyde; 1,3-Dicarbonyls; Knoevenagel Reaction; Cytotoxicity |
| ID Code: | 103839 |
| Deposited On: | 21 Mar 2017 05:17 |
| Last Modified: | 21 Mar 2017 05:17 |
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