β,γ-Bis-substituted PNA with configurational and conformational switch: preferred binding to cDNA/RNA and cell-uptake studies

Bose, Tanaya ; Banerjee, Anjan ; Nahar, Smita ; Maiti, Souvik ; Kumar, Vaijayanti A. (2015) β,γ-Bis-substituted PNA with configurational and conformational switch: preferred binding to cDNA/RNA and cell-uptake studies Chemical Communications, 51 (36). pp. 7693-7696. ISSN 1359-7345

Full text not available from this repository.

Official URL: http://pubs.rsc.org/en/content/articlelanding/2015...

Related URL: http://dx.doi.org/10.1039/C5CC00891C

Abstract

(S,S)- and (R,R)-β,γ-Bis-substituted PNAs were synthesized from the C-2 symmetric vicinal diamine system embedded in 1,4 dihydroxybutane and 1,4-dimethoxybutane scaffolds. (R,R)-β,γ-Bis-methoxymethyl-PNA derived from D-tartaric acid was found to be in the right configuration and conformation to be an excellent mimic of PNA, endowed with superior ability to enter into cells.

Item Type:Article
Source:Copyright of this article belongs to Royal Society of Chemistry.
ID Code:103621
Deposited On:04 Apr 2017 05:53
Last Modified:04 Apr 2017 05:53

Repository Staff Only: item control page