Das, Arghya ; Mukhopadhyay, Sangita (2011) The evil axis of obesity, inflammation and Type-2 Diabetes Endocrine, Metabolic & Immune Disorders - Drug Targets, 11 (1). pp. 23-31. ISSN 1871-5303
Full text not available from this repository.
Official URL: http://www.ingentaconnect.com/content/ben/emiddt/2...
Related URL: http://dx.doi.org/10.2174/187153011794982086
Abstract
Obesity and Type 2 Diabetes (T2D) are global problems affecting all age groups and have been characterized as lifestyle disorders. Though no study has clearly proved a direct correlation between obesity and T2D, a number of factors are associated with obesity causing insulin resistance and T2D. The factors such as adipokines and various transcription factors help to maintain a proper metabolic state in the body. Deregulation in any of these signaling balances due to obesity may trigger an inflammatory cascade which could lead to the aforesaid problems of insulin resistance and T2D. In this review, we have discussed the factors that probably link inflammation to obesity-induced insulin resistance and subsequently T2D and the possible therapeutic opportunities to decrease health risk of T2D in future.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Bentham Science Publishers. |
| Keywords: | Inflammation; Adipokines; Adiponectin; Angiotensinogen; Macrophages/Adipocytes; Monocyte Chemotactic Protein-1; Obesity; Signal Transduction; Sterol Regulatory Element Binding Protein-1; Thiazolidinedione;Triacylglycerol; Type-2 Diabetes |
| ID Code: | 103525 |
| Deposited On: | 09 Mar 2018 10:51 |
| Last Modified: | 09 Mar 2018 10:51 |
Repository Staff Only: item control page
