Population diversity and adaptive evolution in keratinization genes: impact of environment in shaping skin phenotypes

Gautam, Pramod ; Chaurasia, Amit ; Bhattacharya, Aniket ; Grover, Ritika ; Mukerji, Mitali ; Natarajan, Vivek T. (2014) Population diversity and adaptive evolution in keratinization genes: impact of environment in shaping skin phenotypes Molecular Biology and Evolution, 32 (3). pp. 555-573. ISSN 0737-4038

Full text not available from this repository.

Official URL: http://mbe.oxfordjournals.org/content/early/2014/1...

Related URL: http://dx.doi.org/10.1093/molbev/msu342

Abstract

Several studies have demonstrated the role of climatic factors in shaping skin phenotypes, particularly pigmentation. Keratinization is another well-designed feature of human skin, which is involved in modulating trans-epidermal water loss (TEWL). While this physiological process is closely linked to climate, presently it is not clear whether genetic diversity is observed in keratinization and whether this process also responds to the environmental pressure. To address this, we adopted a multipronged approach which involved analysis of (i) copy number variations in diverse Indian and HapMap populations from varied geographical regions; (ii) genetic association with geo-climatic parameters in 61 populations of dbCLINE database in a set of 549 genes from four processes viz. keratinization, pigmentation, epidermal differentiation and housekeeping functions; (iii) sequence divergence in 4316 orthologous promoters and corresponding exonic regions of human and chimpanzee with macaque as out-group, and (iv) protein sequence divergence (Ka/Ks) across nine vertebrate classes which differ in their extent of TEWL. Our analyses demonstrate that keratinization and epidermal differentiation genes are under accelerated evolution in the human lineage, relative to pigmentation and housekeeping genes. We show that this entire pathway may have been driven by environmental selection pressure through concordant functional polymorphisms across several genes involved in skin keratinization. Remarkably, this underappreciated function of skin may be a crucial determinant of adaptation to diverse environmental pressures across world populations.

Item Type:Article
Source:Copyright of this article belongs to Oxford University Press.
Keywords:Keratinization; Comparative Genomics; Non-Coding DNA; Copy-Number Variation; Adaptive Variation; Climatic Factors; Population
ID Code:103464
Deposited On:13 Mar 2017 09:54
Last Modified:05 Jul 2017 12:38

Repository Staff Only: item control page