Bodiwala, HS. ; Sabde, S. ; Mitra, D. ; Bhutani, K.K. ; Singh, I.P. (2009) Anti-HIV diterpenes from Coleus forskohlii Natural Product Communications, 4 (9). pp. 1173-1175. ISSN 1934-578X
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Official URL: http://europepmc.org/abstract/med/19831022
Abstract
Various extracts of the aerial parts of Coleus forskohlii (Labiatae) were prepared and evaluated at their non cytotoxic concentration against HIV-1 NL4-3. Chloroform, ethyl acetate and n-butanol extracts showed 45.6, 66.5 and 37.7% inhibition of HIV, respectively in CEM-GFP cells infected with HIV-1(NL4-3) at 5 microg/mL. Four diterpenes, 1-deoxyforskolin, 1,9-dideoxyforskolin, forskolin and isoforskolin were isolated from the chloroform extract and tested against the virus. Six semi-synthetic derivatives of forskolin have been prepared to study SAR. 1-Deoxyforskolin and forskolin were found to be active against HIV(NL4-3). This is first report of anti HIV activity of this plant and its isolated constituents.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Natural Product Incorporation. |
| ID Code: | 103252 |
| Deposited On: | 05 Feb 2017 16:49 |
| Last Modified: | 05 Feb 2017 16:49 |
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