Bodiwala, Hardik S. ; Sabde, Sudeep ; Gupta, Pawan ; Mukherjee, Ruchira ; Kumar, Rajender ; Garg, Prabha ; Bhutani, Kamlesh Kumar ; Mitra, Debashis ; Singh, Inder Pal (2011) Design and synthesis of caffeoyl-anilides as portmanteau inhibitors of HIV-1 integrase and CCR5 Bioorganic & Medicinal Chemistry, 19 (3). pp. 1256-1263. ISSN 0968-0896
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Official URL: http://www.sciencedirect.com/science/article/pii/S...
Related URL: http://dx.doi.org/10.1016/j.bmc.2010.12.031
Abstract
Designing multi-functional ligands is a recent strategy by which multiple targets can be inhibited by a single entity. A series of caffeoyl-anilide compounds based on structures of various integrase and CCR-5 inhibitors have been designed and synthesized as anti-HIV agents in the present study. Most of the compounds exhibited potent anti-HIV activity at micromolar concentration in CEM-GFP CD4+ T cells infected with HIV-1NL4.3 virus. Compound 14 showed a lower EC50 and better TI as compared to AZT. Mechanism based studies suggest that these compounds inhibit either one or in some cases, both the targets. The experimental data and the docking results showed that these compounds are potential inhibitors for both HIV-1 IN and CCR5.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier. |
| Keywords: | Caffeoyl-Anilide; Anti-HIV; Integrase Inhibitor; CCR5 Inhibitor; Portmanteau Inhibitor |
| ID Code: | 103183 |
| Deposited On: | 05 Feb 2017 16:46 |
| Last Modified: | 05 Feb 2017 16:46 |
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