Brahmbhatt, Keyur G. ; Ahmed, Nafees ; Sabde, Sudeep ; Mitra, Debashis ; Singh, Inder Pal ; Bhutani, Kamlesh K. (2010) Synthesis and evaluation of β-carboline derivatives as inhibitors of Human Immunodeficiency Virus Bioorganic & Medicinal Chemistry Letters, 20 (15). pp. 4416-4419. ISSN 0960-894X
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Official URL: http://www.sciencedirect.com/science/article/pii/S...
Related URL: http://dx.doi.org/10.1016/j.bmcl.2010.06.052
Abstract
A series of β-carboline derivatives were synthesized by utilizing aromatization and chemoselective alkylation method recently reported from our laboratory. Synthesized derivatives were evaluated for anti-HIV activity in human CD4+ T cell line (CEM-GFP) infected with HIV-1 NL4,3 virus. 1-Formyl-β-carboline-3-carbxylic acid methyl ester (15) showed inhibition of human immunodeficiency virus at IC50 = 2.9 μM.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier. |
| Keywords: | Anti-HIV; β-Carboline; 1-Formyl-β-carboline; CEM-GFP cells |
| ID Code: | 103145 |
| Deposited On: | 05 Feb 2017 16:46 |
| Last Modified: | 05 Feb 2017 16:46 |
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