Kar, A. K. ; Ghosh, A. S. ; Chauhan, K. ; Ahamed, J . ; Chakrabarti, P. ; Kundu, M. (1997) Involvement of a 43-kilodalton outer membrane protein in beta-lactam resistance of Shigella dysenteriae Antimicrobial Agents and Chemotherapy, 41 (10). pp. 2302-2304. ISSN 0066-4804
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Official URL: http://aac.asm.org/content/41/10/2302.short
Abstract
A beta-lactam-sensitive strain (C152) of Shigella dysenteriae showed two major outer membrane proteins (OMPs) with M(r)s of 43,000 and 38,000, while the clinical isolate M2 lacked the 43,000-Mr OMP, which acted as a channel for beta-lactam antibiotics. Permeability of beta-lactams across the outer membrane (OM) of M2 was lower than that across the OM of C152. Mutants deficient in the 43-kDa OMP could be selected in vitro from strain C152 in the presence of cefoxitin. All beta-lactam-resistant strains were sensitive to imipenem.
| Item Type: | Article |
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| Source: | Copyright of this article belongs to American Society for Microbiology. |
| ID Code: | 102803 |
| Deposited On: | 11 Mar 2017 13:26 |
| Last Modified: | 11 Mar 2017 13:26 |
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