Shaji, A. V. ; Kulkarni, S. K. ; Agrewala, J. N. (1998) Regulation of secretion of IL-4 and IgG1 isotype by melatonin-stimulated ovalbumin-specific T cells Clinical and Experimental Immunology, 111 (1). pp. 181-185. ISSN 0009-9104
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Official URL: http://onlinelibrary.wiley.com/doi/10.1046/j.1365-...
Related URL: http://dx.doi.org/10.1046/j.1365-2249.1998.00493.x
Abstract
In the present study, we describe the potential role of melatonin, a pineal hormone, in regulating the activation of the antigen-specific T cell response. Melatonin encouraged the proliferation of Th cells and improved their ability to secrete IL-4, but down-regulated the levels of IL-2 and interferon-gamma (IFN-γ). Melatonin, however, could not exert any influence on the T cells of unprimed mice. On studying the regulation of subclass of IgG isotype, melatonin specifically enhanced the secretion of antigen-specific IgG1 antibodies and decreased the yield of IgG2a isotype. The results suggest that melatonin possibly acts by selectively activating a Th2-like immune response.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to John Wiley & Sons, Inc. |
| ID Code: | 101957 |
| Deposited On: | 11 Jan 2017 11:58 |
| Last Modified: | 12 Feb 2018 12:55 |
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