Sharma, Preeti ; Rastogi, Subha ; Bhatnagar, Sunita ; Srivastava, Janmejya K. ; Dube, Anuradha ; Guru, Purushottam Y. ; Kulshrestha, Dinesh K. ; Mehrotra, Bishan N. ; Dhawan, Bhola N. (2003) Antileishmanial action of Tephrosia purpurea linn, extract and its fractions against experimental visceral leishmaniasis Drug Development Research, 60 (4). pp. 285-293. ISSN 0272-4391
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Official URL: http://onlinelibrary.wiley.com/doi/10.1002/ddr.103...
Related URL: http://dx.doi.org/10.1002/ddr.10324
Abstract
Tephrosia purpurea (family: Fabaceae), which is used in traditional remedies for the treatment of febrile attacks, enlargement and obstruction of liver, spleen, and kidney, was found to have significant antileishmanial activity, and has been extensively fractionated to locate the abode of activity. A fraction (F062) obtained from N-butanol extract of T. purpurea showed consistent antileishmanial activity at 50 mg/ kg × 5 days by oral route against Leishmania donovani infection in hamsters. Activity was further confirmed in a secondary model, i.e., Indian langur monkeys (Presbytis entellus). Thus, the fraction F062 from this plant possesses potential to produce significant antileishmanial activity by oral route without producing any toxic side effects.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Wiley. |
| ID Code: | 101815 |
| Deposited On: | 11 Mar 2017 15:06 |
| Last Modified: | 11 Mar 2017 15:06 |
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