Mishra, Pushpesh Kumar ; Singh, Nasib ; Ahmad, Ghufran ; Dube, Anuradha ; Maurya, Rakesh (2005) Glycolipids and other constituents from Desmodium gangeticum with antileishmanial and immunomodulatory activities Bioorganic & Medicinal Chemistry Letters, 15 (20). pp. 4543-4546. ISSN 0960-894X
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Official URL: http://www.sciencedirect.com/science/article/pii/S...
Related URL: http://dx.doi.org/10.1016/j.bmcl.2005.07.020
Abstract
Nineteen compounds of various classes, such as flavonoid glycosides, pterocarpanoids, lipids, glycolipids, and alkaloids, were isolated and identified from the Desmodium gangeticum whole plant. Aminoglucosyl glycerolipid (8) is reported here for the first time. Its structure has been elucidated by spectroscopic and degradation studies. This novel compound exhibited in vitro antileishmanial and immunomodulatory activities, as it enhanced nitric oxide (NO) production and provided resistance against infection established in peritoneal macrophages by the protozoan parasite Leishmania donovani. Another known compound, glycosphingolipid (cerebroside) (7) was found to possess significant in vitro antileishmanial and immunomodulatory activities against the same parasite. Other compounds were found to be inactive.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Desmodium gangeticum; Glycolipids; Flavonoids; Alkaloids; Leishmania donovani; Immunomodulation; Antileishmanial |
| ID Code: | 101789 |
| Deposited On: | 13 Mar 2017 04:36 |
| Last Modified: | 13 Mar 2017 04:36 |
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