Singh, N. K. ; Gupta, A. ; Behera, Dibya R. ; Dash, D. (2013) Elevated plasminogen activator inhibitor type-1 (PAI-1) as contributing factor in pathogenesis of hypercoagulable state in antiphospholipid syndrome Rheumatology International, 33 (9). pp. 2331-2336. ISSN 0172-8172
Full text not available from this repository.
Official URL: http://link.springer.com/article/10.1007/s00296-01...
Related URL: http://dx.doi.org/10.1007/s00296-013-2717-0
Abstract
The aim of this study is to explore the role of plasminogen activator inhibitor type 1 (PAI-1) in primary and secondary antiphospholipid syndrome (APS). Thirty patients of APS (24 primary and 6 secondary) were recruited in the study who fulfilled the revised Sapporo criteria. Control groups comprised of age- and sex-matched 10 healthy volunteers and 10 patients each of systemic lupus erythematosus and rheumatoid arthritis without any antecedent thrombotic event and/or APS-related pregnancy morbidity. Serum samples were tested for PAI-1 antigen levels measured by quantitative ELISA. Positivity rate of PAI-1 in patients of primary, secondary as well as total APS patients was significantly higher in relation to age- and sex-matched healthy volunteers (p = 0.010, p = 0.003 and p < 0.001, respectively). Mean ± SEM levels of PAI-1 in primary and secondary as well as total APS patients were significantly higher (p = 0.006, p < 0.001 and p < 0.001) in relation to healthy controls. Correlation of PAI-1 levels (mean ± SEM) with clinical characteristics, that is, thrombosis and pregnancy morbidity, revealed significantly higher levels of PAI-1 (p < 0.001) in patients having thrombosis and APS-related pregnancy morbidity. Elevated PAI-1 level leading to impaired fibrinolysis plays a significant role in producing hypercoagulable state in primary and secondary APS.
Item Type: | Article |
---|---|
Source: | Copyright of this article belongs to Springer. |
Keywords: | Antiphospholipid Syndrome; Plasminogen Activator Inhibitor Type 1 (PAI-1); Thrombosis |
ID Code: | 101017 |
Deposited On: | 04 Feb 2017 17:22 |
Last Modified: | 04 Feb 2017 17:22 |
Repository Staff Only: item control page