Copper(II) tetrafluoroborate-catalyzed acetylation of phenols, thiols, alcohols, and amines

Chakraborti, Asit K. ; Gulhane, Rajesh (2004) Copper(II) tetrafluoroborate-catalyzed acetylation of phenols, thiols, alcohols, and amines Synthesis, 2004 (1). pp. 111-115. ISSN 0039-7881

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Official URL: https://www.thieme-connect.de/DOI/DOI?10.1055/s-20...

Related URL: http://dx.doi.org/10.1055/s-2003-44362

Abstract

Copper(II) tetrafluoroborate efficiently catalyzes acetyl­ation of structurally diverse phenols, alcohols, thiols, and amines with stoichiometric amounts of Ac2O under solvent-free conditions at room temperature. Acid-sensitive alcohols are smoothly acetylated without competitive side reactions. The reaction is influenced by the steric and electronic factors associated with the substrate as well as the anhydride. Acetylation of a sterically hindered substrate requires excess of anhydride and longer time. Acylation with less electrophilic anhydrides affords poor to moderate yields.

Item Type:Article
Source:Copyright of this article belongs to Thieme Publishing.
Keywords:Acetylation; Copper(II) Tetrafluoroborate; Solvent-Free
ID Code:100659
Deposited On:19 Jan 2017 11:38
Last Modified:19 Jan 2017 11:38

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