Chakraborti, Asit K. (2006) Magnesium bistrifluoromethanesulfonimide as a new and efficient acylation catalyst Journal of Organic Chemistry, 71 (15). pp. 5785-5788. ISSN 0022-3263
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Official URL: http://pubs.acs.org/doi/abs/10.1021/jo0605142
Related URL: http://dx.doi.org/10.1021/jo0605142
Abstract
Magnesium bistrifluoromethanesulfonimide catalyzed the acetylation of phenols, alcohols, and thiols under solvent-free conditions at room temperature and in short times. Electron-deficient and sterically hindered phenols provided excellent yields. The catalyst was found to be general for acylation with other anhydrides, such as propionic, isobutyric, pivalic, chloroacetic, and benzoic anhydrides. The rate of acylation was influenced by the electronic and steric factors associated with the anhydride. The reaction with less electrophilic anhydrides (e.g., chloroacetic and benzoic anhydrides) required higher temperature (∼80 °C). Chemoselective acetylation, pivalation, and benzoylation took place with acid-sensitive alcohols without any competitive dehydration/rearrangement.
Item Type: | Article |
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Source: | Copyright of this article belongs to American Chemical Society. |
ID Code: | 100438 |
Deposited On: | 19 Jan 2017 12:40 |
Last Modified: | 12 Feb 2018 12:56 |
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