Browse by Fellow

Rosencrans, William M. ; Khuntia, Harisankar ; Ghahari Larimi, Motahareh ; Mahalakshmi, Radhakrishnan ; Yu, Tsyr-Yan ; Bezrukov, Sergey M. ; Rostovtseva, Tatiana K. (2025) Conformational plasticity of mitochondrial VDAC2 controls the kinetics of its interaction with cytosolic proteins Science Advances, 11 (17). ISSN 2375-2548

Ravi, Roshika ; Routray, Deepsikha ; Mahalakshmi, Radhakrishnan (2025) Mitochondrial Sorting and Assembly Machinery: Chaperoning a Moonlighting Role? Biochemistry, 64 (2). pp. 312-328. ISSN 0006-2960

Rosencrans, William M. ; Yu, Tsyr-Yan ; Larimi, Motahareh Ghahari ; Mahalakshmi, Radhakrishnan ; Bezrukov, Sergey M. ; Rostovtseva, Tatiana K.R. (2024) Channel conformational plasticity of mitochondrial VDAC2 controls its interaction kinetics with cytosolic proteins Biophysical Journal, 123 (3). 164a. ISSN 0006-3495

George, Anjana ; Patil, Akanksha Gajanan ; Mahalakshmi, Radhakrishnan (2024) ATP‐independent assembly machinery of bacterial outer membranes: BAM complex structure and function set the stage for next‐generation therapeutics Protein Science, 33 (2). ISSN 09618368

Bora, Jinam Ravindra ; Mahalakshmi, Radhakrishnan (2023) Empowering canonical biochemicals with cross‐linked novelty: Recursions in applications of protein cross‐links Proteins: Structure, Function, and Bioinformatics, 93 (1). pp. 11-25. ISSN 0887-3585

Bora, Jinam Ravindra ; Mahalakshmi, Radhakrishnan (2023) Photoradical‐mediated catalyst‐independent protein cross‐link with unusual fluorescence properties ChemBioChem, 24 (17). ISSN 1439-4227

Rosencrans, William M. ; Queralt-Martin, Maria ; Lessen, Henry J. ; Ghahari Larimi, Motahareh ; Rajendran, Megha ; Chou, Tsui-Fen ; Mahalakshmi, Radhakrishnan ; Sodt, Alexander J. ; Yu, Tsyr-Yan ; Bezrukov, Sergey M. ; Rostovtseva, Tatiana K. (2023) Defining the roles and regulation of the mitochondrial VDAC isoforms one molecule at a time Biophysical Journal, 122 (3). 93a. ISSN 0006-3495

Sayyed, Ulfat Mohd. Hanif ; Mahalakshmi, Radhakrishnan (2022) Mitochondrial protein translocation machinery: From TOM structural biogenesis to functional regulation Journal of Biological Chemistry, 298 (5). p. 101870. ISSN 0021-9258

George, Anjana ; Ravi, Roshika ; Tiwari, Pankaj Bharat ; Srivastava, Shashank Ranjan ; Jain, Vikas ; Mahalakshmi, Radhakrishnan (2022) Engineering a hyperstable yersinia pestis outer membrane protein ail using thermodynamic design Journal of the American Chemical Society, 144 (4). pp. 1545-1555. ISSN 0002-7863

Khan, Altmash ; Kuriachan, Gifty ; Mahalakshmi, Radhakrishnan (2021) Cellular interactome of mitochondrial voltage-dependent anion channels: oligomerization and channel (Mis)regulation ACS Chemical Neuroscience, 12 (19). pp. 3497-3515. ISSN 1948-7193

Lella, Muralikrishna ; Mahalakshmi, Radhakrishnan (2021) De novo design of metal‐binding cleft in a Trp‐Trp stapled thermostable β‐hairpin peptide Peptide Science, 113 (6). ISSN 2475-8817

Tiwari, Pankaj B. ; Mahalakshmi, Radhakrishnan (2021) Molecular assembly pathway of mitochondrial SAM50 in native membranes Biophysical Journal, 120 (3). 285a. ISSN 0006-3495

Tiwari, Pankaj B. ; Mahalakshmi, Radhakrishnan (2021) Interplay of protein primary sequence, lipid membrane, and chaperone in β‐barrel assembly Protein Science, 30 (3). pp. 624-637. ISSN 09618368

Srivastava, Shashank Ranjan ; Mahalakshmi, Radhakrishnan (2020) Evolutionary selection of a 19-stranded mitochondrial β-barrel scaffold bears structural and functional significance Journal of Biological Chemistry, 295 (43). pp. 14653-14665. ISSN 0021-9258

Mahalakshmi, Radhakrishnan (2020) Do folding elements trade‐off with function in the human mitochondrial metabolite transporter? The FASEB Journal, 34 (S1). p. 1. ISSN 0892-6638

Rosencrans, William M. ; Queralt-Martin, Maria ; Hoogerheide, David P. ; Gurnev, Philip A. ; Yu, Tsyr-Yan ; Mahalakshmi, Radhakrishnan ; Bezrukov, Sergey M. ; Rostovtseva, Tatiana K. (2020) Dynamic plasticity of mitochondrial VDAC2 revealed by single-molecule electrophysiology Biophysical Journal, 118 (3). 273a. ISSN 0006-3495

Srivastava, Shashank R. ; Mahalakshmi, Radhakrishnan (2020) Linking folding landscape with function in the human mitochondrial VDAC2 Biophysical Journal, 118 (3). 367a. ISSN 0006-3495

Mahalakshmi, Radhakrishnan (2020) Oxidative Thiol Modifications as Molecular Redox Sensors in Human Mitochondria Biophysical Journal, 118 (3). 449a. ISSN 00063495

Gupta, Ankit ; Mahalakshmi, Radhakrishnan (2020) Reversible folding energetics of Yersinia Ail barrel reveals a hyperfluorescent intermediate Biochimica et Biophysica Acta (BBA) - Biomembranes, 1862 (2). p. 183097. ISSN 0005-2736

Gupta, Ankit ; Mahalakshmi, Radhakrishnan (2020) Single-residue physicochemical characteristics kinetically partition membrane protein self-assembly and aggregation Journal of Biological Chemistry, 295 (5). pp. 1181-1194. ISSN 0021-9258

Iyer, Bharat Ramasubramanian ; Gupta, Swadha ; Noordeen, Henna ; Ravi, Roshika ; Pawar, Meera Daulatrao ; George, Anjana ; Mahalakshmi, Radhakrishnan (2019) Molecular switch between structural compaction and thermodynamic stability by the Xxx–Pro interface in transmembrane β-barrels Biochemistry, 59 (3). pp. 303-314. ISSN 0006-2960

Iyer, Bharat Ramasubramanian ; Mahalakshmi, Radhakrishnan (2019) Hydrophobic characteristic is energetically preferred for cysteine in a model membrane protein Biophysical Journal, 117 (1). pp. 25-35. ISSN 0006-3495

Gupta, Ankit ; Mahalakshmi, Radhakrishnan (2019) Helix–strand interaction regulates stability and aggregation of the human mitochondrial membrane protein channel VDAC3 The Journal of General Physiology, 151 (4). pp. 489-504. ISSN 0022-1295

Mahalakshmi, Radhakrishnan (2019) Aromatic interactions in β-hairpin scaffold stability: A historical perspective Archives of Biochemistry and Biophysics, 661 . pp. 39-49. ISSN 0003-9861

Srivastava, Shashank Ranjan ; Zadafiya, Punit ; Mahalakshmi, Radhakrishnan (2018) Hydrophobic mismatch modulates stability and plasticity of human mitochondrial VDAC2 Biophysical Journal, 115 (12). pp. 2386-2394. ISSN 0006-3495

Iyer, Bharat Ramasubramanian ; Vetal, Pallavi Vijay ; Noordeen, Henna ; Zadafiya, Punit ; Mahalakshmi, Radhakrishnan (2018) Salvaging the thermodynamic destabilization of interface histidine in transmembrane βbarrels Biochemistry, 57 (48). pp. 6669-6678. ISSN 0006-2960

Mahalakshmi, Radhakrishnan (2018) Thermodynamic partitioning forces at the membrane protein interface The FASEB Journal, 31 (S1). ISSN 0892-6638

Lella, Muralikrishna ; Mahalakshmi, Radhakrishnan (2018) Direct structural annotation of membrane protein aggregation loci using peptide-based reverse mapping The Journal of Physical Chemistry Letters, 9 (11). pp. 2967-2971. ISSN 1948-7185

Chaturvedi, Deepti ; Mahalakshmi, Radhakrishnan (2018) Folding determinants of transmembrane β-barrels using engineered OMP chimeras Biochemistry, 57 (13). pp. 1987-1996. ISSN 0006-2960

Mahalakshmi, Radhakrishnan (2018) Human mitochondrial VDAC functionality governs scaffold stability Biophysical Journal, 114 (3). 243a. ISSN 0006-3495

Chaturvedi, Deepti ; Mahalakshmi, Radhakrishnan (2018) Position-specific contribution of interface tryptophans on membrane protein energetics Biochimica et Biophysica Acta (BBA) - Biomembranes, 1860 (2). pp. 451-457. ISSN 0005-2736

Chaturvedi, Deepti ; Mahalakshmi, Radhakrishnan (2017) Transmembrane β-barrels: Evolution, folding and energetics Biochimica et Biophysica Acta (BBA) - Biomembranes, 1859 (12). pp. 2467-2482. ISSN 0005-2736

Mahalakshmi, Radhakrishnan ; Maurya, Svetlana Rajkumar ; Burdak, Bhawna ; Surti, Parini ; Patel, Manoj S. ; Jain, Vikas (2017) Structural plasticity of T4 transcription co-activator gp33 revealed by a protease-resistant unfolded state Biochemical and Biophysical Research Communications, 492 (1). pp. 61-66. ISSN 0006-291X

Iyer, Bharat Ramasubramanian ; Zadafiya, Punit ; Vetal, Pallavi Vijay ; Mahalakshmi, Radhakrishnan (2017) Energetics of side-chain partitioning of β-signal residues in unassisted folding of a transmembrane β-barrel protein Journal of Biological Chemistry, 292 (29). pp. 12351-12365. ISSN 0021-9258

Lella, Muralikrishna ; Mahalakshmi, Radhakrishnan (2017) Metamorphic proteins: Emergence of dual protein folds from one primary sequence Biochemistry, 56 (24). pp. 2971-2984. ISSN 0006-2960

Maurya, Svetlana Rajkumar ; Mahalakshmi, Radhakrishnan (2016) Control of human VDAC-2 scaffold dynamics by interfacial tryptophans is position specific Biochimica et Biophysica Acta (BBA) - Biomembranes, 1858 (12). pp. 2993-3004. ISSN 0005-2736

Maurya, Svetlana Rajkumar ; Mahalakshmi, Radhakrishnan (2016) Mitochondrial VDAC2 and cell homeostasis: Highlighting hidden structural features and unique functionalities Biological Reviews, 92 (4). pp. 1843-1858. ISSN 1464-7931

Iyer, Bharat Ramasubramanian ; Gupta, Ankit ; Mahalakshmi, Radhakrishnan (2016) Approaches for preparation and biophysical characterization of transmembrane β-barrels Analysis of Membrane Lipids . pp. 49-116. ISSN 1949-2448

Iyer, Bharat Ramasubramanian ; Mahalakshmi, Radhakrishnan (2016) Distinct structural elements govern the folding, stability, and catalysis in the outer membrane enzyme PagP Biochemistry, 55 (35). pp. 4960-4970. ISSN 0006-2960

De Pinto, Vito ; Reina, Simona ; Gupta, Ankit ; Messina, Angela ; Mahalakshmi, Radhakrishnan (2016) Role of cysteines in mammalian VDAC isoforms' function Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1857 (8). pp. 1219-1227. ISSN 0005-2728

Lella, Muralikrishna ; Mahalakshmi, Radhakrishnan (2016) Solvation driven conformational transitions in the second transmembrane domain of mycobacteriophage holin Peptide Science, 108 (1). ISSN 0006-3525

Lella, Muralikrishna ; Mahalakshmi, Radhakrishnan (2016) Engineering a transmembrane nanopore ion channel from a membrane breaker peptide The Journal of Physical Chemistry Letters, 7 (13). pp. 2298-2303. ISSN 1948-7185

Makwana, Kamlesh M. ; Mahalakshmi, Radhakrishnan (2016) Capping β‐hairpin with N‐terminal d‐amino acid stabilizes peptide scaffold Peptide Science, 106 (3). pp. 260-266. ISSN 0006-3525

Makwana, Kamlesh Madhusudan ; Mahalakshmi, Radhakrishnan (2016) Stereopositional outcome in the packing of dissimilar aromatics in designed β‐hairpins Chemistry – A European Journal, 22 (12). pp. 4147-4156. ISSN 0947-6539

Reina, Simona ; Checchetto, Vanessa ; Saletti, Rosaria ; Gupta, Ankit ; Chaturvedi, Deepti ; Guardiani, Carlo ; Guarino, Francesca ; Scorciapino, Mariano Andrea ; Magrì, Andrea ; Foti, Salvatore ; Ceccarelli, Matteo ; Messina, Angela Anna ; Mahalakshmi, Radhakrishnan ; Szabo, Ildiko ; De Pinto, Vito (2016) VDAC3 as a sensor of oxidative state of the intermembrane space of mitochondria: the putative role of cysteine residue modifications Oncotarget, 7 (3). pp. 2249-2268. ISSN 1949-2553

Maurya, Svetlana Rajkumar ; Mahalakshmi, Radhakrishnan (2015) VDAC‐2: Mitochondrial outer membrane regulator masquerading as a channel? The FEBS Journal, 283 (10). pp. 1831-1836. ISSN 1742-464X

Lella, Muralikrishna ; Kamilla, Soumya ; Jain, Vikas ; Mahalakshmi, Radhakrishnan (2015) Molecular mechanism of holin transmembrane domain I in pore formation and bacterial cell death ACS Chemical Biology, 11 (4). pp. 910-920. ISSN 1554-8929

Maurya, Svetlana Rajkumar ; Mahalakshmi, Radhakrishnan (2015) N-helix and cysteines inter-regulate human mitochondrial VDAC-2 function and biochemistry Journal of Biological Chemistry, 290 (51). pp. 30240-30252. ISSN 0021-9258

Makwana, Kamlesh Madhusudan ; Mahalakshmi, Radhakrishnan (2015) Implications of aromatic–aromatic interactions: From protein structures to peptide models Protein Science, 24 (12). pp. 1920-1933. ISSN 09618368

Iyer, Bharat Ramasubramanian ; Mahalakshmi, Radhakrishnan (2015) Residue-dependent thermodynamic cost and barrel plasticity balances activity in the PhoPQ-activated enzyme PagP of Salmonella Typhimurium Biochemistry, 54 (37). pp. 5712-5722. ISSN 0006-2960

Makwana, Kamlesh M. ; Mahalakshmi, Radhakrishnan (2015) Trp-Trp cross-linking: A structure–reactivity relationship in the formation and design of hyperstable peptide β-hairpin and α-helix scaffolds Organic Letters, 17 (10). pp. 2498-2501. ISSN 1523-7060

Makwana, Kamlesh M. ; Mahalakshmi, Radhakrishnan (2015) NMR analysis of tuning cross-strand Phe/Tyr/Trp–Trp interactions in designed β-hairpin peptides: terminal switch from l to D amino acid as a strategy for β-hairpin capping The Journal of Physical Chemistry B, 119 (17). pp. 5376-5385. ISSN 1520-6106

Makwana, Kamlesh Madhusudan ; Mahalakshmi, Radhakrishnan (2014) Nature of aryl–tyrosine interactions contribute to β-hairpin scaffold stability: NMR evidence for alternate ring geometry Physical Chemistry Chemical Physics, 17 (6). pp. 4220-4230. ISSN 1463-9076

Chaturvedi, Deepti ; Mahalakshmi, Radhakrishnan (2014) Juxtamembrane tryptophans have distinct roles in defining the OmpX barrel–micelle boundary and facilitating protein–micelle association FEBS Letters, 588 (23). pp. 4464-4471. ISSN 0014-5793

Gupta, Ankit ; Iyer, Bharat Ramasubramanian ; Chaturvedi, Deepti ; Maurya, Svetlana Rajkumar ; Mahalakshmi, Radhakrishnan (2014) Thermodynamic, structural and functional properties of membrane protein inclusion bodies are analogous to purified counterparts: case study from bacteria and humans RSC Advances, 5 (2). pp. 1227-1234. ISSN 2046-2069

Gupta, Ankit ; Zadafiya, Punit ; Mahalakshmi, Radhakrishnan (2014) Differential contribution of Tryptophans to the folding and stability of the attachment invasion locus transmembrane β-barrel from Yersinia pestis Scientific Reports, 4 (1). ISSN 2045-2322

Makwana, Kamlesh Madhusudan ; Mahalakshmi, Radhakrishnan (2014) Asymmetric contribution of aromatic interactions stems from spatial positioning of the interacting aryl pairs in β‐hairpins ChemBioChem, 15 (16). pp. 2357-2360. ISSN 1439-4227

Ravikiran, Boddepalli ; Mahalakshmi, Radhakrishnan (2014) Unusual post-translational protein modifications: the benefits of sophistication RSC Advances, 4 (64). pp. 33958-33974. ISSN 2046-2069

Obukhov, Alexander G. ; Maurya, Svetlana Rajkumar ; Mahalakshmi, Radhakrishnan (2014) Cysteine residues impact the stability and micelle interaction dynamics of the human mitochondrial β-barrel anion channel hVDAC-2 PLoS One, 9 (3). e92183. ISSN 1932-6203

Permyakov, Eugene A. ; Maurya, Svetlana Rajkumar ; Mahalakshmi, Radhakrishnan (2014) Influence of protein – micelle ratios and cysteine residues on the kinetic stability and unfolding rates of human mitochondrial VDAC-2 PLoS One, 9 (1). e87701. ISSN 1932-6203

Makwana, Kamlesh Madhusudan ; Mahalakshmi, Radhakrishnan (2013) Comparative analysis of cross strand aromatic–Phe interactions in designed peptide β-hairpins Org. Biomol. Chem., 12 (13). pp. 2053-2061. ISSN 1477-0520

Khan, Rizwan H. ; Chaturvedi, Deepti ; Mahalakshmi, Radhakrishnan (2013) Methionine mutations of outer membrane protein X influence structural stability and beta-barrel unfolding PLoS One, 8 (11). e79351. ISSN 1932-6203

Lella, Muralikrishna ; Mahalakshmi, Radhakrishnan (2013) Pro-Gly mediated conformational switch of mycobacteriophage D29 holin transmembrane domain I is lipid concentration driven Chemical Communications, 49 (83). p. 9594. ISSN 1359-7345

Makwana, Kamlesh Madhusudan ; Raghothama, Srinivasarao ; Mahalakshmi, Radhakrishnan (2013) Stabilizing effect of electrostatic vs. aromatic interactions in diproline nucleated peptide β-hairpins Physical Chemistry Chemical Physics, 15 (37). p. 15321. ISSN 1463-9076

Maurya, Svetlana Rajkumar ; Mahalakshmi, Radhakrishnan (2013) Modulation of human mitochondrial voltage-dependent anion channel 2 (hVDAC-2) structural stability by cysteine-assisted barrel-lipid interactions Journal of Biological Chemistry, 288 (35). pp. 25584-25592. ISSN 0021-9258

Maurya, Svetlana Rajkumar ; Chaturvedi, Deepti ; Mahalakshmi, Radhakrishnan (2013) Modulating lipid dynamics and membrane fluidity to drive rapid folding of a transmembrane barrel Scientific Reports, 3 (1). ISSN 2045-2322

Plesniak, Leigh A. ; Mahalakshmi, Radhakrishnan ; Rypien, Candace ; Yang, Yuan ; Racic, Jasmina ; Marassi, Francesca M. (2011) Expression, refolding, and initial structural characterization of the Y. pestis Ail outer membrane protein in lipids Biochimica et Biophysica Acta (BBA) - Biomembranes, 1808 (1). pp. 482-489. ISSN 0005-2736

Mahalakshmi, Radhakrishnan ; Marassi, Francesca M. (2008) Orientation of the Escherichia coli outer membrane protein OmpX in phospholipid bilayer membranes determined by solid-state NMR Biochemistry, 47 (25). pp. 6531-6538. ISSN 0006-2960

Mahalakshmi, Radhakrishnan ; Franzin, Carla M. ; Choi, Jungyuen ; Marassi, Francesca M. (2007) NMR structural studies of the bacterial outer membrane protein OmpX in oriented lipid bilayer membranes Biochimica et Biophysica Acta (BBA) - Biomembranes, 1768 (12). pp. 3216-3224. ISSN 0005-2736

Mahalakshmi, Radhakrishnan ; Balaram, Padmanabhan (2006) Non-protein amino acids in the design of secondary structure scaffolds pp. 71-94.