Neonatal rotavirus infection and its relation to cord blood antibodies

Jayashree, Srinivasan ; Bhan, Maharaj Kumar ; Raj, Pushker ; Kumar, Ramesh ; Svensson, Lennart ; Stintzing, Gudmund ; Bhandari, Nita (1988) Neonatal rotavirus infection and its relation to cord blood antibodies Scandinavian Journal of Infectious Diseases, 20 (3). pp. 249-253. ISSN 0036-5548

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Among 274 neonates born at the maternity services of an urban hospital in India, 36.1% of the infants shed rotavirus in feces (as detected by ELISA) by 72 h of life. The excretion rate increased to 70.3% among the 120 infants who stayed for 5 days or more at the hospital. Diarrhoeal symptoms of mild and self-limited nature were observed only in 19.2% of the rotavirus excretors, the remaining being asymptomatic. Among the 98 infants who received supplement feeds, 49% acquired rotavirus infection as against 24.7% of the 150 exclusively breast fed infants (p less than 0.001). Viral RNA in the feces of all rota positive infants showed the same electropherotype, indicating infection from a common source. The mean percentage rotavirus inhibitory activity of cord sera in the infected and non-infected infants was 50.2 +/- 21.7 and 56.6 +/- 19.2 respectively (p greater than 0.05), suggesting that cord blood antibodies do not offer significant protection against neonatal rotavirus infection.

Item Type:Article
Source:Copyright of this article belongs to Taylor & Francis.
ID Code:99963
Deposited On:28 Nov 2016 06:48
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