The impact of vitamin A supplementation on physical growth of children is dependent on season

Bahl, R. ; Bhandari, N. ; Taneja, S. ; Bhan, M. K. (1997) The impact of vitamin A supplementation on physical growth of children is dependent on season European Journal of Clinical Nutrition, 51 (1). pp. 26-29. ISSN 0954-3007

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OBJECTIVE:To determine the impact of vitamin A supplementation on physical growth in young children. DESIGN: Randomized, double blind, placebo controlled trial. SETTING: Urban slum community clinic. SUBJECTS: 900 children, aged 12-59 months, attending the community clinic with diarrhea of < or = 7 d were included in the trial. INTERVENTION: Each child was given a single dose capsule containing 200,000 IU vitamin A or placebo at enrollment. MAIN OUTCOME MEASURES: Mean increments in weight and height during the 90 d period post supplementation. RESULTS: In all children, the mean increments in weight following supplementation were 0.66 kg (s.d. 0.5) and 0.64 kg (s.d. 0.6) in the vitamin A and placebo groups (P = 0.5). The mean increments in height were also similar in the two treatment groups (P = 0.5). Serum vitamin A was measured in 40 randomly selected children in each group; the proportion of subclinical deficiency (serum retinol < 20 micrograms/dl) was 62.5% in those enrolled during summer (April through July) as compared to 21.1% in those enrolled during the remaining cooler months of the year (P = 0.02). In the children supplemented with vitamin A during summer, the mean increment in weight was 140 g more than those who received placebo (95% confidence interval CI 30-250); there was also a significant reduction in the proportion of children who were wasted (< -2 weight-for-height Z-score) at end study (Odds Ratio 0.53, 95% CI 0.28-1.0, P = 0.03). There was no significant impact of vitamin A on height increments in children supplemented during summer. CONCLUSION: Vitamin A supplementation in 12-59 month old children improves weight gain in the subsequent three months only in the summer season, but not during the rest of the year. Discover the world's research

Item Type:Article
Source:Copyright of this article belongs to Nature Publishing Group.
Keywords:Vitamin A; Supplementation; Physical Growth; Children
ID Code:99884
Deposited On:28 Nov 2016 10:52
Last Modified:28 Nov 2016 10:52

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