Effect of routine zinc supplementation on pneumonia in children aged 6 months to 3 years: randomised controlled trial in an urban slum

Bhandari, Nita ; Bahl, Rajiv ; Taneja, Sunita ; Strand, Tor ; Mølbak, Kare ; Ulvik, Rune Johan ; Sommerfelt, Halvor ; Bhan, Maharaj K. (2002) Effect of routine zinc supplementation on pneumonia in children aged 6 months to 3 years: randomised controlled trial in an urban slum BMJ: British Medical Journal, 324 . p. 1358. ISSN 0959-8138

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Official URL: http://www.bmj.com/content/324/7350/1358

Related URL: http://dx.doi.org/10.1136/bmj.324.7350.1358

Abstract

Objective: To evaluate the effect of daily zinc supplementation in children on the incidence of acute lower respiratory tract infections and pneumonia. Design: Double masked, randomised placebo controlled trial. Setting: A slum community in New Delhi, India. Participants: 2482 children aged 6 to 30 months. Interventions: Daily elemental zinc, 10 mg to infants and 20 mg to older children or placebo for four months. Both groups received single massive dose of vitamin A (100 000 IU for infants and 200 000 IU for older children) at enrolment. Main outcome measures: All households were visited weekly. Any children with cough and lower chest indrawing or respiratory rate 5 breaths per minute less than the World Health Organization criteria for fast breathing were brought to study physicians. Results: At four months the mean plasma zinc concentration was higher in the zinc group (19.8 (SD 10.1) v 9.3 (2.1) μmol/l, P<0.001). The proportion of children who had acute lower respiratory tract infection during follow up was no different in the two groups (absolute risk reduction −0.2%, 95% confidence interval −3.9% to 3.6%). Zinc supplementation resulted in a lower incidence of pneumonia than placebo (absolute risk reduction 2.5%, 95% confidence interval 0.4% to 4.6%). After correction for multiple episodes in the same child by generalised estimating equations analysis the odds ratio was 0.74, 95% confidence interval 0.56 to 0.99. Conclusions: Zinc supplementation substantially reduced the incidence of pneumonia in children who had received vitamin A.

Item Type:Article
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ID Code:99865
Deposited On:28 Nov 2016 11:34
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