Water-mediated supramolecular β-sheet from a short synthetic peptide containing non-coded amino acids

Abstract

The crystal structure of a synthetic, terminally blocked tetrapeptide t-Boc-β-Ala-L-Leu-Aib-L-Val-OMe reveals that the peptide adopts an overall extended backbone conformation. It self-assembles in the solid state to form an intermolecularly hydrogen-bonded β-sheet-like structure mediated by water molecules.