Molecular basis of pathogenesis in amoebiasis

Saha, Arpita ; Gaurav, Amit Kumar ; Bhattacharya, Sudha ; Bhattacharya, Alok (2015) Molecular basis of pathogenesis in amoebiasis Current Clinical Microbiology Reports, 2 (4). pp. 143-154. ISSN 2196-5471

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Amoebiasis is one of the major public health problems in developing countries. In spite of the availability of an effective drug and absence of overt drug resistance, the disease is still prevalent among large population and spread over a number of countries. It is caused by the protist parasite Entamoeba histolytica that essentially infects humans, though other species that infect a few animals have been reported. A number of molecular techniques have recently been developed. These have helped in understanding biological processes in E. histolytica and in the identification of key molecules that are involved in amoebic virulence and invasion. Moreover, developments in the area of disease and invasion models have allowed understanding of these processes at molecular level and circumvented lack of a good animal model of amoebiasis. All these knowledge will help us to design better therapeutics and allow us to control this important disease.

Item Type:Article
Source:Copyright of this article belongs to Springer International Publishing.
Keywords:Entamoeba histolytica; Amoebiasis; Cysteine Proteases; Phagocytosis
ID Code:99598
Deposited On:01 Dec 2016 11:51
Last Modified:01 Dec 2016 11:51

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