Karothu, Durga Prasad ; Trinath, Jamma ; Biswas, Ansuman ; Kanagaraj, Sekar ; Balaji, Kithiganahalli N. ; Guru Row, Tayur N. (2014) Alkyl chain substituted 1,9-pyrazoloanthrones exhibit prominent inhibitory effect on c-Jun N-terminal kinase (JNK) Organic & Biomolecular Chemistry, 12 (26). pp. 4656-4662. ISSN 1477-0520
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Official URL: http://pubs.rsc.org/en/Content/ArticleLanding/2014...
Related URL: http://dx.doi.org/10.1039/c4ob00548a
Abstract
N-Alkyl substituted pyrazoloanthrone derivatives were synthesized, characterized and tested for their in vitro inhibitory activity over c-Jun N-terminal kinase (JNK). Among the tested molecules, a few derivatives showed significant inhibitory activity against JNK with minimal off-target effect on other mitogen-activated protein kinase (MAP kinase) family members such as MEK1/2 and MKK3,6. These results suggested that N-alkyl (propyl and butyl) bearing pyrazoloanthrone scaffolds provide promising therapeutic inhibitors for JNK in regulating inflammation associated disorders
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Royal Society of Chemistry. |
| ID Code: | 99595 |
| Deposited On: | 26 Nov 2016 11:53 |
| Last Modified: | 26 Nov 2016 11:53 |
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