X-ray crystallographic signature of supramolecular triple helix formation from a water soluble synthetic tetrapeptide

Das, Apurba Kumar ; Haldar, Debasish ; Hegde, Raghurama P. ; Shamala, N. ; Banerjee, Arindam (2005) X-ray crystallographic signature of supramolecular triple helix formation from a water soluble synthetic tetrapeptide Chemical Communications (14). pp. 1836-1838. ISSN 1359-7345

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Official URL: http://pubs.rsc.org/en/Content/ArticleLanding/2005...

Related URL: http://dx.doi.org/10.1039/B417726F

Abstract

Single crystal X-ray diffraction studies on the water soluble, synthetic tetrapeptide Tyr(1)-Aib(2)-Tyr(3)-Val(4) with a non-coded amino acid residue (Aib: [small alpha]-amino isobutyric acid) reveal that the peptide adopts an "S"-shaped molecular structure which self-assembles to form a supramolecular triple helix using various non-covalent interactions including water mediated hydrogen bonds in the solid state.

Item Type:Article
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