Banerjee, Arijit ; Maji, Samir Kumar ; Drew, Michael G. B. ; Haldar, Debasish ; Banerjee, Arindam (2003) An amyloid-like fibril forming antiparallel supramolecular β-sheet from a synthetic tripeptide: a crystallographic signature Tetrahedron Letters, 44 (35). pp. 6741-6744. ISSN 0040-4039
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Official URL: http://www.sciencedirect.com/science/article/pii/S...
Related URL: http://dx.doi.org/10.1016/S0040-4039(03)01642-3
Abstract
Single crystal X-ray diffraction studies of a terminally blocked tripeptide Boc-Leu(1)-Aib(2)-Leu(3)-OMe 1 demonstrates that it adopts a bend structure without any intramolecular hydrogen bond. Peptide 1 self-assembles to form a supramolecular antiparallel beta-sheet structure by various non-covalent interactions including intermolecular hydrogen bonds in the crystal and it exhibits amyloid-like fibrillar morphology in the solid state.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Aib; Antiparallel β-Sheet; Amyloid-Like Fibrils; Self-Assembly |
| ID Code: | 99524 |
| Deposited On: | 07 Nov 2016 11:22 |
| Last Modified: | 12 Feb 2018 12:21 |
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