Dynamicity of immune regulation during visceral leishmaniasis

Asad, M. D. ; Ali, Nahid (2014) Dynamicity of immune regulation during visceral leishmaniasis Proceedings of the Indian National Science Academy, 80 (2). pp. 247-267. ISSN 0370-0046

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Official URL: http://www.insa.nic.in/UI/Journalarticle.aspx?jid=...

Related URL: http://dx.doi.org/10.16943/ptinsa/2014/v80i2/55105


Visceral leishmaniasis is a vector-borne tropical disease associated with a spectrum of clinical manifestations and immunosuppression leading to parasite survival. Chemokines which act as chemo-attractants for generating innate immune responses are significant in bringing innate and adaptive responses side by side for combating against infection. The independency and interdependency of regulatory T cells and Th17 cells on Th1/Th2 signalling pathways and an imbalance in immune responses could lead to disease progression. Although Interleukin- (IL-)12 is crucial in generating protective Th 1 response against the disease, various members of the IL-12 family perform diverse immune functions due to their chain pairing promiscuity. This review focuses on the immunopathogenesis of VL by chronologically summarising the developments in the studies of the immune regulation as well as the mechanisms involved. A better understanding of the innate and adaptive immune functioning of the host could aid in rational control and better therapeutic intervention of the disease.

Item Type:Article
Source:Copyright of this article belongs to Indian National Science Academy.
Keywords:Immunology; Leishmaniasis; Cytokine; Chemokine; Regulatory Cell; Immune Cell; Innate Immunity; Adaptive Immunity; Memory Response
ID Code:99473
Deposited On:27 Oct 2016 10:57
Last Modified:27 Oct 2016 11:00

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