Antileishmanial activities of stearylamine-bearing liposomes

Dey, Tuhina ; Anam, Khairul ; Afrin, Farhat ; Ali, Nahid (2000) Antileishmanial activities of stearylamine-bearing liposomes Antimicrobial Agents and Chemotherapy, 44 (6). pp. 1739-1742. ISSN 0066-4804

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Here we report the activity of liposomes comprising egg phosphatidylcholine (PC) and stearylamine (SA) against Leishmania donovani parasites. Both promastigotes and intracellular amastigotes in vitro and in vivo were susceptible to SA-PC liposomes. A single dose of 55 mg of SA-PC liposomes/animal could significantly reduce the hepatic parasite burden by 85 and 68% against recent and established experimental visceral leishmaniasis, respectively, suggesting their strong therapeutic potential.

Item Type:Article
Source:Copyright of this article belongs to American Society for Microbiology.
ID Code:98474
Deposited On:28 Jul 2014 10:55
Last Modified:19 May 2016 10:28

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