Palit, P. ; Ali, N. (2008) Oral therapy with amlodipine and lacidipine, 1,4-dihydropyridine derivatives showing activity against experimental visceral leishmaniasis Antimicrobial Agents and Chemotherapy, 52 (1). pp. 374-377. ISSN 0066-4804
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Official URL: http://aac.asm.org/content/52/1/374
Related URL: http://dx.doi.org/10.1128/AAC.00522-07
Abstract
Amlodipine and lacidipine, conventional antihypertensive drugs, inhibited Leishmania donovani infection in vitro and in BALB/c mice when administered orally. These 1,4-dihydropyridine derivatives functioned through dose-dependent inhibition of oxygen consumption, triggering caspase 3-like activation-mediated programmed cell death of the parasites.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Society for Microbiology. |
| ID Code: | 98456 |
| Deposited On: | 23 Jul 2014 09:42 |
| Last Modified: | 23 Jul 2014 09:42 |
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