Epigenetic regulation of transcription by RNA polymerase III

Bhargava, Purnima (2013) Epigenetic regulation of transcription by RNA polymerase III Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 1829 (10). pp. 1015-1025. ISSN 1874-9399

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Official URL: http://www.sciencedirect.com/science/article/pii/S...

Related URL: http://dx.doi.org/10.1016/j.bbagrm.2013.05.005


Chromatin participates actively in all DNA transactions and all phenomena directly under the influence of chromatin are explained by epigenetic mechanisms. The genes transcribed by RNA polymerase (pol) III are generally found in regions free of nucleosomes, the structural units of chromatin. Yet, histone modifications and positions of nucleosomes in the gene flanking regions have been reported to show direct correlation with activity status of these genes. Gene-specific as well as genome-wide studies have also revealed association of several epigenetic components with pol III-transcribed genes. This review presents a summary of the research in past many years, which have gathered enough evidence to conclude that pol III-transcribed genes are important components of an epigenome.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:RNA Polymerase III; Chromatin Remodeling; H2A.Z; Nucleosome Positioning; Histone Modifications; Histone Chaperones
ID Code:98044
Deposited On:29 Jan 2014 11:21
Last Modified:29 Jan 2014 11:21

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